Nogo B Receptor anticorps (AA 167-210) (Alexa Fluor 350)

N° du produit ABIN1391445

Détail du produit anti-Nogo B Receptor anticorps (Alexa Fluor 350)

Antigène: Nogo B Receptor (NUS1)

Épitope: AA 167-210

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nogo B Receptor est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Nogo B Receptor

Antigène: Nogo B Receptor (NUS1)

Autre désignation: NGBR/Nogo B receptor (NUS1 Produits)

Synonymes: anticorps C6orf68, anticorps MGC:7199, anticorps NgBR, anticorps TANGO14, anticorps 1600027K07Rik, anticorps AU019165, anticorps AW538011, anticorps BC003223, anticorps D10Ertd438e, anticorps NUS1 dehydrodolichyl diphosphate synthase subunit, anticorps NUS1, anticorps Nus1

Sujet:

Synonyms: C6orf68, NGBR, nuclear undecaprenyl pyrophosphate synthase 1 homolog, NUS1, NGBR_HUMAN, Dehydrodolichyl diphosphate synthase complex subunit NUS1, Cis-prenyltransferase subunit NgBR, Nogo-B receptor.

Background: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.

ID gène: 116150

UniProt: Q96E22