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SHARPIN anticorps (AA 260-310) (AbBy Fluor® 350)

SHARPIN Reactivité: Humain, Rat, Souris WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 350
N° du produit ABIN1403511
  • Antigène Voir toutes SHARPIN Anticorps
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Épitope
    • 14
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 260-310
    Reactivité
    • 45
    • 23
    • 18
    • 2
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 44
    • 1
    Polyclonal
    Conjugué
    • 18
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHARPIN est conjugé à/à la AbBy Fluor® 350
    Application
    • 41
    • 18
    • 12
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SHARPIN
    Isotype
    IgG
    Top Product
    Discover our top product SHARPIN Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Autre désignation
    SHARPIN (SHARPIN Produits)
    Synonymes
    anticorps 0610041B22Rik, anticorps AW121341, anticorps RBCKL1, anticorps SIPL1, anticorps cpdm, anticorps Conneck1, anticorps SHANK-associated RH domain interacting protein, anticorps SHANK associated RH domain interactor, anticorps SHANK-associated RH domain interactor, anticorps Sharpin, anticorps SHARPIN
    Sujet

    Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216

    Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

    ID gène
    81858
    UniProt
    Q9H0F6
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