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Retinoic Acid Induced 12 (RAI12) anticorps (Alexa Fluor 488)

RAI12 Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal Alexa Fluor 488
N° du produit ABIN1403800
  • Antigène Voir toutes Retinoic Acid Induced 12 (RAI12) Anticorps
    Retinoic Acid Induced 12 (RAI12)
    Reactivité
    • 21
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    Lapin
    Clonalité
    • 21
    Polyclonal
    Conjugué
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Alexa Fluor 488
    Application
    • 20
    • 12
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DERP6/C17orf81
    Isotype
    IgG
    Top Product
    Discover our top product RAI12 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Retinoic Acid Induced 12 (RAI12)
    Autre désignation
    DERP6 (RAI12 Produits)
    Synonymes
    anticorps C17orf81, anticorps DERP6, anticorps MST071, anticorps MSTP071, anticorps Derp6, anticorps Rai12, anticorps derp6, anticorps rai12, anticorps zgc:158278, anticorps zgc:158285, anticorps elongator acetyltransferase complex subunit 5, anticorps ELP5, anticorps Elp5, anticorps elp5
    Sujet

    Synonyms: MST071, MSTP071, chromosome 17 open reading frame 81, Dermal papilla derived protein 6, dermal papilla-derived protein 6, DERP6, HSPC002, S phase 2 protein, ELP5_HUMAN.

    Background: DERP6, is a 316 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in liver, heart, testis, brain and skeletal muscle, DERP6 is thought to be involved in p53-mediated transcriptional regulation. The gene encoding DERP6 maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

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