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GFR anticorps (AA 151-250) (Cy5)

RAPGEF5 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN1410016
  • Antigène Voir toutes GFR (RAPGEF5) Anticorps
    GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))
    Épitope
    • 14
    • 8
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reactivité
    • 49
    • 13
    • 6
    Humain
    Hôte
    • 47
    • 3
    Lapin
    Clonalité
    • 49
    • 1
    Polyclonal
    Conjugué
    • 16
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GFR est conjugé à/à la Cy5
    Application
    • 37
    • 23
    • 12
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human RAPGEF5
    Isotype
    IgG
    Top Product
    Discover our top product RAPGEF5 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))
    Autre désignation
    RAPGEF5/Repac (RAPGEF5 Produits)
    Synonymes
    anticorps GFR, anticorps MR-GEF, anticorps REPAC, anticorps 4932413M22, anticorps C86120, anticorps D030051B22Rik, anticorps Mrgef, anticorps mKIAA0277, anticorps mmr-gef, anticorps RGD1562891, anticorps rMR-GEF, anticorps MGC154311, anticorps Rap guanine nucleotide exchange factor 5, anticorps Rap guanine nucleotide exchange factor (GEF) 5, anticorps Rap guanine nucleotide exchange factor 5 S homeolog, anticorps RAPGEF5, anticorps Rapgef5, anticorps rapgef5.S
    Sujet

    Synonyms: GFR, Guanine nucleotide exchange factor for Rap1, KIAA0277, M Ras regulated Rap GEF, M-Ras-regulated Rap GEF, MR GEF, MR-GEF, MRGEF, Rap guanine nucleotide exchange factor 5, Rapgef5, Related to Epac, Repac, RPGF5_HUMAN.

    Background: Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.

    Pathways
    Signalisation RTK, Neurotrophin Signaling Pathway, Hepatitis C
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