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APBB3 anticorps (AA 401-486) (Cy5)

APBB3 Reactivité: Rat, Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN1410340
  • Antigène Voir toutes APBB3 Anticorps
    APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))
    Épitope
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-486
    Reactivité
    • 18
    • 16
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat, Souris
    Hôte
    • 26
    • 3
    Lapin
    Clonalité
    • 27
    • 1
    Polyclonal
    Conjugué
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APBB3 est conjugé à/à la Cy5
    Application
    • 29
    • 12
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Dog,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human APBB3/FE65L2
    Isotype
    IgG
    Top Product
    Discover our top product APBB3 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))
    Autre désignation
    APBB3/FE65L2 (APBB3 Produits)
    Synonymes
    anticorps Fe65l2, anticorps Rirl2, anticorps TR2S, anticorps MGC142933, anticorps FE65L2, anticorps SRA, anticorps amyloid beta (A4) precursor protein-binding, family B, member 3, anticorps steroid receptor RNA activator 1, anticorps amyloid beta precursor protein binding family B member 3, anticorps Apbb3, anticorps SRA1, anticorps APBB3, anticorps apbb3
    Sujet

    Synonyms: Amyloid beta A4 precursor protein binding family B member 3, Amyloid beta A4 precursor protein-binding family B member 3, amyloid beta precursor protein binding family B member 3, amyloid precursor interacting protein, Apbb3, APBB3_HUMAN, Fe65 like protein 2, FE65L2, Protein Fe65-like 2, SRA.

    Background: Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6 % of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

    ID gène
    10307
    UniProt
    O95704
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