ARFGEF2 anticorps (AA 761-860) (Cy3)

N° du produit ABIN1411311

Détail du produit anti-ARFGEF2 anticorps (Cy3)

Antigène: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Épitope: AA 761-860

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARFGEF2 est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ARFGEF2/BIG2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ARFGEF2

Antigène: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Autre désignation: ARFGEF2/BIG2 (ARFGEF2 Produits)

Synonymes: anticorps AI463430, anticorps AW493672, anticorps BIG2, anticorps E230011G24Rik, anticorps Big2, anticorps PVNH2, anticorps dJ1164I10.1, anticorps ADP ribosylation factor guanine nucleotide exchange factor 2, anticorps ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), anticorps ARFGEF2, anticorps Arfgef2

Sujet:

Synonyms: ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited, ADP ribosylation factor guanine nucleotide exchange factor 2, ARFGEF 2, ARFGEF2, ARFGEP2, BIG 2, BIG2, Brefeldin A inhibited 2, Brefeldin A inhibited GEP 2, Brefeldin A inhibited guanine nucleotide exchange protein 2, dJ1164I10.1, BIG2_HUMAN.

Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.