GFAP anticorps

N° du produit ABIN1449150

Détail du produit anti-GFAP anticorps

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GFAP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: CQIRETpSLD TKS

Specificité: This antibody reacts with non phosphorylated GFAP and phosphorylated GFAP.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogène: KLH conjugated synthetic peptide

Clone: MO389

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GFAP

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Autre désignation: GFAP (GFAP Produits)

Synonymes: anticorps GFAP, anticorps AI836096, anticorps cb345, anticorps etID36982.3, anticorps gfapl, anticorps wu:fb34h11, anticorps wu:fk42c12, anticorps xx:af506734, anticorps zgc:110485, anticorps glial fibrillary acidic protein, anticorps GFAP, anticorps LOC100136168, anticorps gfap, anticorps Gfap

Sujet: Intermediate filaments (IFs) constitute major components of the cytoskeleton and the nuclear envelope in most cell types. Unlike other cytoskeletons such as microtubules and actin filaments, the protein components of IFs vary in a cell-, tissue-, and differentiation-dependent manner. Although IFs were thought to be relatively stable compared with actin filaments and microtubules, intensive in vitro investigations revealed that site-specific phosphorylation by several kinases, such as protein kinase A (PKA), protein kinase C (PKC), Ca2+/Calmodulin kinase II (CaMKII), cdc2 kinase, and Rho-kinase alters dynamically their structure and induces filament disruption. Glial fibrillary acidic protein (GFAP) belongs to IF proteins. GFAP is a useful marker of mature astrocytes and mutation in the GFAP gene has recently been associated with Alexander disease. Inagaki et al. reported that GFAP was phosphorylated specifically at Thr-7, Ser-13, and Ser-34 by Rho-kinase and Aurora-B and all of these sites were phosphorylated at the cleavage furrow during cytokinesis.Synonyms: Glial Fibrillary Acidic Protein

Poids moléculaire: approx. 50 kDa

ID gène: 2670

NCBI Accession: NP_001229305

UniProt: P14136