CD46 anticorps

N° du produit ABIN1449263

Détail du produit anti-CD46 anticorps

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Purification: Protein A agarose

Immunogène: Human pancreatic carcinoma cell line (AsPC1)

Clone: TGP3

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur CD46

Antigène: CD46

Autre désignation: CD46 / MCP (CD46 Produits)

Synonymes: anticorps AHUS2, anticorps MCP, anticorps MIC10, anticorps TLX, anticorps TRA2.10, anticorps Mcp, anticorps CD46, anticorps CD46 molecule, anticorps CD46 antigen, complement regulatory protein, anticorps CD46 molecule, complement regulatory protein, anticorps membrane cofactor protein-like, anticorps CD46, anticorps Cd46, anticorps LOC100341359, anticorps LOC103789310

Sujet: CD46, also known as membrane cofactor protein (MCP), was first described as a membrane complement regulator that fu nctions as a cofactor with factor I to cleave complement factors C3b and C4b and thereby protect the cell from co mplement attack. In humans, CD46 is expressed on all nuc leated cells. In the rodent animals, its expression is limited only in testis, indicating that the major function of CD46 among different species lies in fertilization. CD46 and other membrane complement regulatory proteins (CD55 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Several pathogens, including viruses and bacteria (measles virus, human herpesvirus 6, human group B and D adenoviruses, Streptococcus pyogenes , and pathogenic Neisseria species) have been reported to use CD46 for invasion. Recent evidence also indicates that CD 46 signaling events play an important role in linking innate and acquired immune function.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

ID gène: 9606

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization