SDHD anticorps (Middle Region)

N° du produit ABIN1449927

Détail du produit anti-SDHD anticorps

Antigène: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SDHD est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid synthetic peptide near the center of Human SDHD

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SDHD

Antigène: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Autre désignation: SDHD (SDHD Produits)

Synonymes: anticorps RATSDHE1, anticorps SDH2, anticorps Sdh, anticorps Sdhe1, anticorps TDH, anticorps 3110001M13Rik, anticorps AVLL5809, anticorps C78570, anticorps PRO19626, anticorps CII-4, anticorps CII4, anticorps QPs3, anticorps cybS, anticorps CybS, anticorps CBT1, anticorps CWS3, anticorps PGL, anticorps PGL1, anticorps SDH4, anticorps MSN2.16, anticorps MSN2_16, anticorps succinate dehydrogenase 1-1, anticorps CybS-B, anticorps cbt1, anticorps pgl, anticorps pgl1, anticorps sdh4, anticorps cybS-B, anticorps sdhd, anticorps sdhda, anticorps zgc:100986, anticorps serine dehydratase, anticorps succinate dehydrogenase complex, subunit D, integral membrane protein, anticorps succinate dehydrogenase complex subunit D, anticorps succinate dehydrogenase 1-1, anticorps succinate dehydrogenase complex subunit D, integral membrane protein L homeolog, anticorps succinate dehydrogenase complex, subunit D, integral membrane protein b, anticorps Sds, anticorps Sdhd, anticorps SDHD, anticorps SDH1-1, anticorps sdhd.L, anticorps sdhdb

Sujet: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.Synonyms: CII-4, CybS, QPs3, SDH4, Succinate dehydrogenase [ubiquinone] cytochrome b small subunit mitochondrial, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor subunit

ID gène: 6392

NCBI Accession: NP_002993