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SPINK7/ECRG2 anticorps (C-Term)

SPINK7 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Poulet Polyclonal unconjugated
N° du produit ABIN1450063
  • Antigène Voir toutes SPINK7/ECRG2 (SPINK7) Anticorps
    SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))
    Épitope
    • 15
    • 2
    C-Term
    Reactivité
    • 18
    • 17
    • 8
    • 3
    Humain, Souris, Rat
    Hôte
    • 25
    • 1
    Poulet
    Clonalité
    • 26
    Polyclonal
    Conjugué
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SPINK7/ECRG2 est non-conjugé
    Application
    • 21
    • 13
    • 13
    • 12
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    16 amino acid synthetic peptide near the carboxy terminus of Human ECRG2
    Top Product
    Discover our top product SPINK7 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))
    Autre désignation
    ECRG-2 (SPINK7 Produits)
    Synonymes
    anticorps Ecg2, anticorps Ecrg2, anticorps OM, anticorps ECG2, anticorps ECRG2, anticorps EG408198, anticorps serine peptidase inhibitor, Kazal type 7, anticorps serine peptidase inhibitor, Kazal type 7 (putative), anticorps Spink7, anticorps SPIK7, anticorps SPINK7
    Sujet
    The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.Synonyms: ECG2, Esophagus cancer-related gene 2 protein, MGC133105, MGC133106, SPINK7, Serine protease inhibitor Kazal-type 7, UNQ745/PRO1474
    ID gène
    84651
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