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BRCA1 anticorps (AA 120-220)

BRCA1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1512646
  • Antigène Voir toutes BRCA1 Anticorps
    BRCA1 (Breast Cancer 1 (BRCA1))
    Épitope
    • 22
    • 18
    • 15
    • 15
    • 14
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 120-220
    Reactivité
    • 192
    • 36
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 161
    • 37
    • 2
    Lapin
    Clonalité
    • 165
    • 35
    Polyclonal
    Conjugué
    • 93
    • 18
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp BRCA1 est non-conjugé
    Application
    • 126
    • 67
    • 42
    • 42
    • 41
    • 36
    • 29
    • 24
    • 22
    • 12
    • 12
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    DEVSIIQSMG YRNRAKRLLQ SEPENPSLQE TSLSVQLSNL GTVRTLRTKQ RIQPQKTSVY IELGSDSSED TVNKATYCSV GDQELLQITP QGTRDEISLD S
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    A synthetic peptide corresponding to a sequence within amino acids 120-220 of human BRCA1 (NP_009225.1).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze / thaw cycles
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Yin, Liu, Peng, Peng, Yu, Gao, Yuan, Zhu, Cao, He, Gong, Sun, Fan, Li: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." dans: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).

    Penn, Yang, Zong, Lim, Cole, Yang, Baker, Goonewardena, Buckanovich: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." dans: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).

  • Antigène
    BRCA1 (Breast Cancer 1 (BRCA1))
    Autre désignation
    BRCA1 (BRCA1 Produits)
    Synonymes
    anticorps BRCAI, anticorps BRCC1, anticorps BROVCA1, anticorps IRIS, anticorps PNCA4, anticorps PPP1R53, anticorps PSCP, anticorps RNF53, anticorps iris, anticorps pscp, anticorps brcai, anticorps brcc1, anticorps rnf53, anticorps brca1, anticorps BRCA1, anticorps LOC100224649, anticorps BRCA1, DNA repair associated, anticorps breast cancer 1, anticorps breast cancer 1, early onset, anticorps breast cancer 1 L homeolog, anticorps BRCA1, anticorps brca1, anticorps LOC755086, anticorps Brca1, anticorps brca1.L
    Sujet
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.,BRCA1,BRCAI,BRCC1,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,PSCP,RNF53,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,G2/M DNA Damage Checkpoint,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,BRCA1
    Poids moléculaire
    7 kDa/78-85 kDa/202-210 kDa
    ID gène
    672
    UniProt
    P38398
    Pathways
    Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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