Tyrosine Hydroxylase (TH) anticorps

Détails pour le produit réf. ABIN152458
Antigène
  • DYT14
  • DYT5b
  • TYH
  • The
  • CG10118
  • DH65B
  • DTH
  • Dmel\\CG10118
  • Pale
  • Ple
  • TH
  • Th
  • VII
  • dTH1
  • dTH65B
  • pale/ple
  • th
  • dyt14
  • dyt5b
  • tyh
  • tyrosine hydroxylase
  • pale
  • tyrosine 3-monooxygenase
  • tyrosine hydroxylase S homeolog
  • TH
  • Th
  • ple
  • th
  • th.S
Reactivité
Mouche des fruits (Drosophila melanogaster), Humain, Insectes, Mammifères, Souris, Rat (Rattus)
260
241
174
19
18
16
11
10
5
3
3
3
3
3
2
1
1
1
1
1
Hôte
Lapin
259
49
16
14
10
Clonalité
Polyclonal
Conjugué
Inconjugué
10
6
6
6
6
6
6
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Free Floating) (IHC (ff)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Simple Western (SimWes), Western Blotting (WB)
266
184
141
67
53
38
37
27
17
14
13
7
3
2
2
Options
Immunogène SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma
Specificité Specific for the ~60k tyrosine hydroxylase protein.
Purification Immunogen affinity purified
Antigène
Autre désignation Tyrosine Hydroxylase (TH Antibody Extrait)
Sujet Gene Symbol: TH
Poids moléculaire Theoretical MW: 60 kDa
ID gène 7054
UniProt P07101
Pathways Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
Indications d'application Western Blot 1:1000, Simple Western 2 μg/mL, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:1000, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:1000, Immunohistochemistry Free-Floating, Immunofluorescence 1:10 - 1:500Immunohistochemistry: use reported in literature (PMID: 22262884 and PMID: 23811324). Use in rat and mouse reported in customer review. Use in Immunohistochemistry-Free floating reported in scientific literature (PMID 25731749) In Simple Western only 10 - 15 μL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Commentaires

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 0.15 mg/mL
Buffer 10 mM HEPES ( pH 7.5), 0.15M NaCl, 0.1 mg/mL BSA and 50 % Glycerol
Buffer contains: No Preservative
Agent conservateur Without preservative
Conseil sur la manipulation Avoid freeze-thaw cycles
Stock -20 °C
Stockage commentaire Store at -20°C. Avoid freeze-thaw cycles.
Images (Fournisseur)
Immunofluorescence (IF) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunohistochemical staining of retina tissue during ABIN152458.
Immunofluorescence (IF) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunocytochemistry/Immunofluorescence: Tyrosine Hydroxylase Antibody [ABIN152458] - ...
Immunofluorescence (IF) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunocytochemistry/Immunofluorescence: Tyrosine Hydroxylase Antibody [ABIN152458] - ...
Immunofluorescence (IF) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunocytochemistry/Immunofluorescence: Tyrosine Hydroxylase Antibody [ABIN152458] - ...
Immunofluorescence (IF) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunocytochemistry/Immunofluorescence: Tyrosine Hydroxylase Antibody [ABIN152458] - ...
Western Blotting (WB) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Western Blot: Tyrosine Hydroxylase Antibody [ABIN152458] - WB analysis of Tyrosine Hy...
Western Blotting (WB) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Western Blot: Tyrosine Hydroxylase Antibody [ABIN152458] - 10 ug of rat caudate lysat...
Simple Western (SimWes) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Simple Western: Tyrosine Hydroxylase Antibody [ABIN152458] - Simple Western lane view...
Western Blotting (WB) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Western Blot: Tyrosine Hydroxylase Antibody - Western blot of 10 ug of rat striatal ...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunohistochemistry-Paraffin: Tyrosine Hydroxylase Antibody - Immunohistochemical a...
Immunocytochemistry (ICC) image for anti-Tyrosine Hydroxylase (TH) antibody (ABIN152458) Immunocytochemistry: Tyrosine Hydroxylase Antibody - 10x Magnification cryo-sections...
Produit citée dans: Kishinevsky, Wang, Rodina, Chung, Xu, Philip, Taldone, Joshi, Alpaugh, Bolaender, Gutbier, Sandhu, Fattahi, Zimmer, Shah, Chang, Inda, Koren, Saurat, Leist, Gross, Seshan, Klein, Tomishima et al.: "HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. ..." dans: Nature communications, Vol. 9, Issue 1, pp. 4345, 2019 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Human).

Borkar, Bharne, Nagalakshmi, Sakharkar, Subhedar, Kokare: "Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms." dans: Neuroscience, Vol. 375, pp. 94-107, 2019 (PubMed).

Rinaldi, Seguella, Gigli, Hanieh, Del Favero, Cantù, Pesce, Sarnelli, Marianecci, Esposito, Carafa: "inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice." dans: Journal of controlled release : official journal of the Controlled Release Society, Vol. 294, pp. 17-26, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (IHC) (Échantillon (espèces): Mouse (Murine)).

Villadiego, Romo-Madero, García-Swinburn, Suárez-Luna, Bermejo-Navas, Echevarría, Toledo-Aral: "Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy." dans: Xenotransplantation, Vol. 25, Issue 6, pp. e12410, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (IHC) (Échantillon (espèces): Mouse (Murine)).

Kim, Park, Leem, Cho, Yoon, Maeng, Lee: "Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress." dans: International journal of molecular sciences, Vol. 20, Issue 7, 2019 (PubMed). Méthode utilisée: Immunofluorescence (fixed cells) (IF/ICC) (Échantillon (espèces): Human).

Thayer, Awad, Hegdekar, Sarkar, Tesfay, Burt, Zeng, Feldman, Lipinski: "The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability." dans: Autophagy, pp. 1-14, 2019 (PubMed). Méthode utilisée: Immunofluorescence (fixed cells) (IF/ICC) (Échantillon (espèces): Human).

Chen, Kordich, Williams, Levine, Cole-Strauss, Marshall, Labrie, Ma, Lipton, Moore: "Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 12, pp. 5765-5774, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (IHC) (Échantillon (espèces): Mouse (Murine)).

Hajji, Mteyrek, Sun, Cassar, Mezghani, Leprince, Vaudry, Masmoudi-Kouki, Birman: "Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system." dans: Human molecular genetics, Vol. 28, Issue 11, pp. 1905-1918, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (Whole Mount) (IHC (wm)) (Échantillon (espèces): Fruit Fly (Drosophila melanogaster)).

Maksoud, Liao, Haghighi: "A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration." dans: Cell reports, Vol. 26, Issue 7, pp. 1774-1786.e4, 2019 (PubMed). Méthode utilisée: Immunofluorescence (fixed cells) (IF/ICC) (Échantillon (espèces): Fruit Fly (Drosophila melanogaster)).

Deng, Li, Liu, Cao, Li, Qian, Xu, Mao, Zhou, Zhang, Huang, Rao: "Chemoconnectomics: Mapping Chemical Transmission in Drosophila." dans: Neuron, Vol. 101, Issue 5, pp. 876-893.e4, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (Whole Mount) (IHC (wm)) (Échantillon (espèces): Fruit Fly (Drosophila melanogaster)).

Bechmann, Poser, Seifert, Greunke, Ullrich, Qin, Walch, Peitzsch, Robledo, Pacak, Pietzsch, Richter, Eisenhofer: "Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells." dans: Cancers, Vol. 11, Issue 5, 2019 (PubMed). Méthode utilisée: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Échantillon (espèces): Mouse (Murine)).

Alekseyenko, Chan, Okaty, Chang, Dymecki, Kravitz: "Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways." dans: Current biology : CB, Vol. 29, Issue 13, pp. 2145-2156.e5, 2019 (PubMed).

Kim, Kwon, Kam, Panicker, Karuppagounder, Lee, Lee, Kim, Kook, Foss, Shen, Lee, Kulkarni, Pasricha, Lee, Pomper, Dawson, Dawson, Ko: "Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease." dans: Neuron, 2019 (PubMed). (Échantillon (espèces): Mouse (Murine)).

Kamiya, Hayama, Kato, Shimomura, Shimomura, Irie, Kaneko, Yanagawa, Kobayashi, Ochiya: "Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression." dans: Nature neuroscience, Vol. 22, Issue 8, pp. 1289-1305, 2019 (PubMed). Méthode utilisée: Immunohistochemistry (IHC)

El-Desouky, Taalab, El-Gamal, Mohamed, Salama: "Animal Model for Leigh Syndrome." dans: Methods in molecular biology (Clifton, N.J.), Vol. 2011, pp. 451-464, 2019 (PubMed). (Échantillon (espèces): Human).

Kang, Jo, Kim, Khang, Lee, Kim, Park, Choi, Lee, Shin: "PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration." dans: Biochemical and biophysical research communications, Vol. 495, Issue 4, pp. 2498-2504, 2018 (PubMed). Méthode utilisée: Immunohistochemistry (IHC) (Échantillon (espèces): Human).

Kim, Yun, Lee, Umanah, Bandaru, Yin, Rhee, Karuppagounder, Kwon, Lee, Mao, Kim, Pandey, Lee, Dawson, Dawson, Ko: "GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 4, pp. 798-803, 2018 (PubMed).

Wang, Zhou: "Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation." dans: Frontiers in pharmacology, Vol. 8, pp. 935, 2018 (PubMed).

Sun, Xu, Giraud, Poppinga, Riemensperger, Fiala, Birman: "Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila." dans: Frontiers in systems neuroscience, Vol. 12, pp. 6, 2018 (PubMed).

Kim, Hwang, Choi, Kwon, Lee, Park, Kim, Ko: "D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model." dans: Acta neuropathologica communications, Vol. 6, Issue 1, pp. 32, 2018 (PubMed).

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