HLA-DMB anticorps (AA 127-154)

N° du produit ABIN1537808

Détail du produit anti-HLA-DMB anticorps

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Épitope: AA 127-154

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DMB est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the Central region of human HLA-DMB.

Clone: RB31771

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: HLA-DMB Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur HLA-DMB

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Autre désignation: HLA-DMB (HLA-DMB Produits)

Synonymes: anticorps RING7, anticorps D6S221E, anticorps RT1.DMb, anticorps RT1.Mb, anticorps MHC-DMB, anticorps major histocompatibility complex, class II, DM beta, anticorps RT1 class II, locus DMb, anticorps HLA-DMB, anticorps RT1-DMb, anticorps PATR-DMB

Sujet: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Poids moléculaire: 28943

ID gène: 3109

NCBI Accession: NP_002109

UniProt: P28068

Pathways: Cancer Immune Checkpoints