DBN1 anticorps (AA 1-326)

N° du produit ABIN1558079

Détail du produit anti-DBN1 anticorps

Antigène: DBN1 (Drebrin 1 (DBN1))

Épitope: AA 1-326

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBN1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Specificité: The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Clone: DBN-N-03

Isotype: IgG2b

Information d'application

Indications d'application: Western blotting: Positive control: REH, Nalm-6, HEK293 cells.
Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur DBN1

Antigène: DBN1 (Drebrin 1 (DBN1))

Autre désignation: Drebrin (DBN1 Produits)

Synonymes: anticorps D0S117E, anticorps DBN1, anticorps LOC733967, anticorps drebrin 1, anticorps drebrin 1 S homeolog, anticorps DBN1, anticorps Dbn1, anticorps dbn1.S, anticorps dbn1

Sujet: Drebrin 1,Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.,DBN, D0S117E

ID gène: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location