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Nicastrin anticorps (AA 429-669)

NCSTN Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1681053
  • Antigène Voir toutes Nicastrin (NCSTN) Anticorps
    Nicastrin (NCSTN)
    Épitope
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 429-669
    Reactivité
    • 39
    • 34
    • 23
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 52
    • 3
    Lapin
    Clonalité
    • 44
    • 11
    Polyclonal
    Conjugué
    • 22
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Nicastrin est non-conjugé
    Application
    • 41
    • 13
    • 13
    • 9
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Séquence
    RFLRARNISG VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL E
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 429-669 of human NCSTN (NP_056146.1).
    Isotype
    IgG
    Top Product
    Discover our top product NCSTN Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    Nicastrin (NCSTN)
    Autre désignation
    NCSTN (NCSTN Produits)
    Synonymes
    anticorps CG7012, anticorps Dmel\\CG7012, anticorps Nct, anticorps Nic, anticorps S5A, anticorps ST96B, anticorps agro, anticorps dNct, anticorps nic, anticorps NCSTN, anticorps DKFZp469O2418, anticorps APH2, anticorps 9430068N19Rik, anticorps AA727311, anticorps Aph2, anticorps D1Dau13e, anticorps Kiaa0253, anticorps mKIAA0253, anticorps nicastrin, anticorps Nicastrin, anticorps NCSTN, anticorps nct, anticorps ncstn, anticorps CpipJ_CPIJ001617, anticorps Ncstn, anticorps aph-2
    Sujet
    This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease, however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.,NCSTN,ATAG1874,nicastrin,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,Stem Cells,NCSTN
    Poids moléculaire
    76 kDa/78 kDa
    ID gène
    23385
    UniProt
    Q92542
    Pathways
    Signalisation Notch, Neurotrophin Signaling Pathway
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