GEMIN6 anticorps (AA 21-120) (Alexa Fluor 350)

N° du produit ABIN1693044

Détail du produit anti-GEMIN6 anticorps (Alexa Fluor 350)

Antigène: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Épitope: AA 21-120

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEMIN6 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Gemin 6

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GEMIN6

Antigène: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Autre désignation: Gemin 6 (GEMIN6 Produits)

Sujet:

Synonyms: FLJ23459, Gemin6, Gemin-6, Gem nuclear organelle associated protein 6, Gem-associated protein 6, GEMI6, GEMI6_HUMAN, Gemin-6, GEMIN6, SIP2.

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (Survival of Motor Neuron) gene. Gemin6, the protein product of human chromosome 2p22.2, associates directly with SMN and is a part of the SMN complex containing Gemin2, Gemin3, Gemin4 and Gemin5 as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. The SMN complex is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies).

ID gène: 79833

Pathways: Ribonucleoprotein Complex Subunit Organization