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NGEF anticorps (pTyr179) (Alexa Fluor 350)

NGEF Reactivité: Humain, Souris, Rat WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 350
N° du produit ABIN1693212
  • Antigène Voir toutes NGEF Anticorps
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Épitope
    • 15
    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr179
    Reactivité
    • 36
    • 36
    • 29
    • 4
    • 4
    • 4
    • 4
    Humain, Souris, Rat
    Hôte
    • 43
    • 1
    Lapin
    Clonalité
    • 43
    • 1
    Polyclonal
    Conjugué
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NGEF est conjugé à/à la Alexa Fluor 350
    Application
    • 40
    • 25
    • 25
    • 12
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179
    Isotype
    IgG
    Top Product
    Discover our top product NGEF Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Autre désignation
    Ephexin-1 (NGEF Produits)
    Synonymes
    anticorps Ephexin-1, anticorps ARHGEF27, anticorps EPHEXIN, anticorps Tims2, anticorps ephexin, anticorps Besh3, anticorps ephexin-1, anticorps neuronal guanine nucleotide exchange factor, anticorps NGEF, anticorps Ngef
    Sujet

    Synonyms: Ephexin-1 phospho Y179, p-Ephexin-1 phospho Y179, ARHGEF27, Eph-interacting exchange protein, EPHEXIN, Ephexin 1, Neuronal guanine nucleotide exchange factor, Ngef, NGEF_HUMAN.

    Background: EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.

    ID gène
    25791
    Pathways
    Neurotrophin Signaling Pathway
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