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GMEB2 anticorps (AA 101-200) (Alexa Fluor 350)

GMEB2 Reactivité: Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 350
N° du produit ABIN1693288
  • Antigène Voir toutes GMEB2 Anticorps
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Épitope
    • 14
    • 2
    • 1
    • 1
    AA 101-200
    Reactivité
    • 25
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 1
    Souris
    Hôte
    • 29
    Lapin
    Clonalité
    • 29
    Polyclonal
    Conjugué
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GMEB2 est conjugé à/à la Alexa Fluor 350
    Application
    • 20
    • 12
    • 12
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GMEB2
    Isotype
    IgG
    Top Product
    Discover our top product GMEB2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Autre désignation
    GMEB2 (GMEB2 Produits)
    Synonymes
    anticorps GMEB2, anticorps P79PIF, anticorps PIF79, anticorps AI839884, anticorps glucocorticoid modulatory element binding protein 2, anticorps glucocorticoid modulatory element binding protein 2 S homeolog, anticorps GMEB2, anticorps gmeb2.S, anticorps Gmeb2
    Sujet

    Synonyms: GMEB2, DNA binding protein p79P, DNA-binding protein p79P, Glucocorticoid modulatory element binding protein 2, Glucocorticoid modulatory element-binding protein 2, GMEB 2, GMEB-2, Gmeb2, GMEB2_HUMAN, KIAA1269, P79P, Parvovirus initiation factor p79, P p79, P79, RP4 663D7.1.

    Background: GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.

    ID gène
    26205
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