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GCS1 anticorps (AA 51-150) (Alexa Fluor 350)

MOGS Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 350
N° du produit ABIN1693684
  • Antigène Voir toutes GCS1 (MOGS) Anticorps
    GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))
    Épitope
    • 14
    • 10
    • 9
    • 7
    • 7
    • 1
    • 1
    AA 51-150
    Reactivité
    • 52
    • 14
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 53
    Lapin
    Clonalité
    • 53
    Polyclonal
    Conjugué
    • 20
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GCS1 est conjugé à/à la Alexa Fluor 350
    Application
    • 53
    • 31
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GCS1
    Isotype
    IgG
    Top Product
    Discover our top product MOGS Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))
    Autre désignation
    GCS1 (MOGS Produits)
    Synonymes
    anticorps Afu6g04210, anticorps AO090701000141, anticorps Mogs, anticorps CDG2B, anticorps CWH41, anticorps DER7, anticorps GCS1, anticorps 1810017N02Rik, anticorps AI181835, anticorps Gcs1, anticorps gcs1, anticorps im:7160827, anticorps wu:fe50a12, anticorps wu:fk09a10, anticorps zgc:158312, anticorps mannosyl-oligosaccharide glucosidase, anticorps mannosyl-oligosaccharide glucosidase GCS1, anticorps mannosyl-oligosaccharide glucosidase L homeolog, anticorps mannosyl oligosaccharide glucosidase, anticorps glucosidase 1, anticorps AFUA_6G04210, anticorps Tc00.1047053511015.10, anticorps Tc00.1047053511805.10, anticorps LOC5576381, anticorps AOR_1_260114, anticorps MGYG_00305, anticorps TERG_01248, anticorps mogs.L, anticorps TTHERM_00636930, anticorps LOAG_03690, anticorps Gcs1, anticorps MOGS, anticorps Mogs, anticorps mogs
    Sujet

    Synonyms: EC 3.2.1.106, glucosidase I, Mannosyl oligosaccharide glucosidase, Mannosyl-oligosaccharide glucosidase, Mogs, MOGS_HUMAN, Processing A glucosidase I, Processing A-glucosidase I.

    Background: Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER). Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway. It specifically removes the distal alpha 1,2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor. Glucosidase I contains a short cytosolic tail, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER. Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), which is characterized by generalized hypotonia, dysmorphic features, hepatomegaly, hypoventilation, feeding problems, seizures and death. Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, namely Arg486Thr and Phe652Leu, that affect polypeptide folding and active site formation.

    ID gène
    7841
    Pathways
    SARS-CoV-2 Protein Interactome
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