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GARNL1 anticorps (AA 631-730) (Alexa Fluor 488)

RALGAPA1 Reactivité: Rat IF (cc), IF (p) Hôte: Lapin Polyclonal Alexa Fluor 488
N° du produit ABIN1695229
  • Antigène Voir toutes GARNL1 (RALGAPA1) Anticorps
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    Épitope
    • 14
    • 1
    • 1
    • 1
    AA 631-730
    Reactivité
    • 23
    • 14
    • 10
    Rat
    Hôte
    • 26
    • 2
    Lapin
    Clonalité
    • 26
    • 2
    Polyclonal
    Conjugué
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GARNL1 est conjugé à/à la Alexa Fluor 488
    Application
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GARNL1
    Isotype
    IgG
    Top Product
    Discover our top product RALGAPA1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    Autre désignation
    GARNL1 (RALGAPA1 Produits)
    Synonymes
    anticorps GARNL1, anticorps GRIPE, anticorps TULIP1, anticorps Garnl1, anticorps Tulip1, anticorps tulip1, anticorps tulip1.2, anticorps 2310003F20Rik, anticorps 4930400K19Rik, anticorps AI563624, anticorps mKIAA0884, anticorps p240, anticorps Ral GTPase activating protein catalytic alpha subunit 1, anticorps Ral GTPase activating protein, alpha subunit 1 (catalytic), anticorps Ral GTPase activating protein, alpha subunit 1, anticorps RALGAPA1, anticorps Ralgapa1, anticorps ralgapa1
    Sujet

    Synonyms: DKFZp566D133, DKFZp667F074, GAP related interacting partner to E12, GARN L1, GARNL 1, GRIPE, GTPase activating Rap/RanGAP domain like 1, KIAA0884, Tuberin like protein 1, TULIP 1. TULIP1, RGPA1_HUMAN.

    Background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.

    ID gène
    253959
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