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APOBEC3C anticorps (AA 121-190) (Biotin)

APOBEC3C Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1699861
  • Antigène Voir toutes APOBEC3C Anticorps
    APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
    Épitope
    • 14
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-190
    Reactivité
    • 31
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 26
    • 4
    • 1
    Lapin
    Clonalité
    • 29
    • 2
    Polyclonal
    Conjugué
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APOBEC3C est conjugé à/à la Biotin
    Application
    • 27
    • 13
    • 13
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human APOBEC3C
    Isotype
    IgG
    Top Product
    Discover our top product APOBEC3C Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
    Autre désignation
    APOBEC3C (APOBEC3C Produits)
    Synonymes
    anticorps APOBEC3C, anticorps A3C, anticorps APOBEC1L, anticorps ARDC2, anticorps ARDC4, anticorps ARP5, anticorps PBI, anticorps bK150C2.3, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3C, anticorps apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C, anticorps APOBEC3C
    Sujet

    Synonyms: ABC3C_HUMAN, APOBEC1 like, APOBEC1-like, APOBEC1L, APOBEC3C, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C, ARDC2, ARDC4, ARP5, bK150C2.3, MGC19485, PBI, Phorbolin I, Phorbolin I protein, Probable DNA dC dU editing enzyme APOBEC 3C, Probable DNA dC->dU-editing enzyme APOBEC-3C.

    Background: APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.

    ID gène
    27350
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