This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010].
Synonyms: Actin related protein 2/3 complex subunit 4, Actin related protein 2/3 complex subunit 4 20 kD, Actin related protein 2/3 complex subunit 4 20 kDa, Actin-related protein 2/3 complex subunit 4, ARC20, Arp2/3 complex 20 kDa subunit, Arp2/3 protein complex subunit p20, ARPC 4, ARPC4, ARPC4_HUMAN, MGC13544, OTTHUMP00000165252, OTTHUMP00000207520, p20 Arc, p20-ARC, p20ARC.