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GGA1 anticorps (AA 51-150) (Cy5)

GGA1 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN1704922
  • Antigène Voir toutes GGA1 Anticorps
    GGA1 (Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1))
    Épitope
    • 14
    • 14
    • 10
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reactivité
    • 53
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 6
    Lapin
    Clonalité
    • 50
    • 4
    Polyclonal
    Conjugué
    • 27
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GGA1 est conjugé à/à la Cy5
    Application
    • 33
    • 28
    • 15
    • 12
    • 12
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GGA1
    Isotype
    IgG
    Top Product
    Discover our top product GGA1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GGA1 (Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1))
    Autre désignation
    GGA1 (GGA1 Produits)
    Synonymes
    anticorps 4930406E12Rik, anticorps AU016030, anticorps AW209092, anticorps fb33h10, anticorps im:6912200, anticorps wu:fb33h10, anticorps zgc:101044, anticorps putative golgi associated, gamma adaptin ear containing,arf binding protein 1 (gga1), anticorps golgi associated, gamma adaptin ear containing, ARF binding protein 1, anticorps golgi-associated, gamma adaptin ear containing, ARF binding protein 1, anticorps Smp_164030, anticorps Gga1, anticorps gga1, anticorps GGA1
    Sujet

    Synonyms: 4930406E12Rik, ADP ribosylation factor binding protein 1, ADP ribosylation factor binding protein GGA1, ADP-ribosylation factor-binding protein GGA1, ARF binding protein 1, ARF-binding protein 1, Gamma adaptin related protein 1, gamma ear-containing, Gamma-adaptin-related protein 1, GGA 1, GGA1, GGA1 protein, GGA1_HUMAN, Golgi associated gamma adaptin ear containing ARF, Golgi associated gamma adaptin ear containing ARF binding protein 1, Golgi localized gamma ear containing ARF binding protein 1, Golgi-localized, OTTHUMP00000028975, OTTHUMP00000042200.

    Background: The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45 % sequence identity with GGA2 and GGA3 (1).

    ID gène
    26088
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