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IQSEC2 anticorps (AA 851-950) (FITC)

IQSEC2 Reactivité: Souris IF (cc), IF (p) Hôte: Lapin Polyclonal FITC
N° du produit ABIN1709553
  • Antigène Voir toutes IQSEC2 Anticorps
    IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
    Épitope
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 851-950
    Reactivité
    • 18
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 19
    • 1
    Lapin
    Clonalité
    • 20
    Polyclonal
    Conjugué
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IQSEC2 est conjugé à/à la FITC
    Application
    • 12
    • 12
    • 6
    • 5
    • 5
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human IQSEC2
    Isotype
    IgG
    Top Product
    Discover our top product IQSEC2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
    Autre désignation
    IQSEC2 (IQSEC2 Produits)
    Synonymes
    anticorps BRAG1, anticorps MRX1, anticorps Brag1, anticorps mKIAA0522, anticorps RGD1562109, anticorps IQ motif and Sec7 domain 2, anticorps IQSEC2, anticorps Iqsec2
    Sujet

    Synonyms: BRAG1, IQ mot and SEC7 domain-containing protein 2, IQEC2_HUMAN, Iqsec2, KIAA0522, mKIAA0522, MRX1, RP11-258C19.1.

    Background: IQSEC2 is a 1,478 amino acid protein that belongs to the BRAG family and contains one IQ domain, one PH domain and a SEC7 domain. Localizing to the cytoplasm, IQSEC2 is expressed in brain, kidney and small intestine, with weaker levels of expression in placenta, pancreas, ovary, prostate and liver. IQSEC2 is a component of the postsynaptic density at excitatory synapses, and interacts with ARF family members as a guanine nucleotide exchange factor. Through the activation of ARF substrates, IQSEC2 may play a crucial role in cytoskeletal and synaptic organization. The gene encoding IQSEC2 maps to the human X chromosome. Defects to the IQSEC2 gene have been linked to mental retardation X-linked type 1 (MRX1), a condition characterized by decreased intellectual function. IQSEC2 exists as three isoforms due to alternative splicing events.

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