ACAA1 is a 424 amino acid member of the thiolase family of enzymes and is involved in lipid metabolism. Localized to the peroxisome, ACAA1 catalyzes the conversion of acyl-CoA and acetyl-CoA to 3-oxoacyl-CoA in the fatty acid oxidation pathway. ACAA1 shows high enzymatic activity in liver, kidney, intestine and white adipose tissue in rats, where it exists as two types, namely type A and type B. Human ACAA1 shares 86 % amino acid identity with its rat counterpart, suggesting a conserved function for ACAA1 among different species.
Synonyms: 3 ketoacyl CoA thiolase peroxisomal, 3-ketoacyl-CoA thiolase, ACAA, ACAA1, Acetyl CoA acyltransferase 1, Acetyl Coenzyme A acyltransferase 1, Acetyl-CoA acyltransferase, Acetyl-Coenzyme A acyltransferase 1 peroxisomal 3 oxoacyl Coenzyme A, Beta ketothiolase, Beta-ketothiolase, Peroxisomal 3 oxoacyl CoA thiolase, Peroxisomal 3 oxoacyl Coenzyme A thiolase, Peroxisomal 3-oxoacyl-CoA thiolase, peroxisomal, PTHIO, THIK_HUMAN, THIO.