ANAPC11 anticorps (AA 1-84) (HRP)

N° du produit ABIN1712104

Détail du produit anti-ANAPC11 anticorps (HRP)

Antigène: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Épitope: AA 1-84

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANAPC11 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human APC11

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ANAPC11

Antigène: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Autre désignation: APC11 (ANAPC11 Produits)

Synonymes: anticorps APC11, anticorps Apc11p, anticorps anapc11, anticorps RGD1561880, anticorps F10A16.17, anticorps F10A16_17, anticorps anaphase-promoting complex/cyclosome 11, anticorps DDBDRAFT_0187183, anticorps DDBDRAFT_0231277, anticorps DDB_0187183, anticorps DDB_0231277, anticorps 1110011I19Rik, anticorps R75218, anticorps zgc:153671, anticorps si:dkey-237i9.4, anticorps anaphase promoting complex subunit 11, anticorps anaphase promoting complex subunit 11 L homeolog, anticorps anaphase-promoting complex/cyclosome 11, anticorps anaphase-promoting complex subunit Apc11, anticorps ubiquitin-protein ligase Anaphase Promoting Complex, anticorps hypothetical protein, anticorps predicted protein, anticorps anaphase-promoting complex subunit 11, anticorps APC11 anaphase promoting complex subunit 11 homolog (yeast), anticorps ANAPC11, anticorps anapc11.L, anticorps anapc11, anticorps Anapc11, anticorps APC11, anticorps apc11, anticorps CAALFM_CR10610CA, anticorps LOC9320604, anticorps LOC692923

Sujet:

Synonyms: ANAPC 11, ANAPC11, Anaphase promoting complex subunit 11, Anaphase promoting complex subunit 11 homolog yeast, Anaphase promoting complex subunit 11 homolog, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p, APC11 anaphase promoting complex subunit 11 homolog yeast, APC11 anaphase promoting complex subunit 11 homolog, APC11, APC11_HUMAN, Apc11p, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, Hepatocellular carcinoma-associated RING finger protein, HSPC 214, HSPC214, MGC882, Yeast APC 11 homolog, Yeast APC11 homolog.

Background: Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC?s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

ID gène: 51529