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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008].
Synonyms: Histone H4 Acetyl K5, Histone H4 Acetyl Lys5, Acetyl-Histone H4 Lys5, H4F2, H4FN, HIST1H4, HIST2H4, HISTH4H4, methyl histone H4, histone H4, H4_HUMAN.