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GEM anticorps (AA 201-296) (HRP)

GEM Reactivité: Humain WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1712312
  • Antigène Voir toutes GEM Anticorps
    GEM (GTP Binding Protein Overexpressed in Skeletal Muscle (GEM))
    Épitope
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-296
    Reactivité
    • 32
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 29
    • 2
    • 1
    Lapin
    Clonalité
    • 31
    • 1
    Polyclonal
    Conjugué
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GEM est conjugé à/à la HRP
    Application
    • 31
    • 14
    • 13
    • 13
    • 8
    • 8
    • 6
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human GEM
    Isotype
    IgG
    Top Product
    Discover our top product GEM Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GEM (GTP Binding Protein Overexpressed in Skeletal Muscle (GEM))
    Autre désignation
    GEM (GEM Produits)
    Synonymes
    anticorps KIR, anticorps GEM, anticorps DKFZp470D0612, anticorps LOC100221129, anticorps kir, anticorps xgem, anticorps zgc:153003, anticorps Gem, anticorps AV020497, anticorps GTP binding protein overexpressed in skeletal muscle, anticorps geminin, DNA replication inhibitor, anticorps GTP binding protein (gene overexpressed in skeletal muscle), anticorps GEM, anticorps gem, anticorps Gem, anticorps GMNN
    Sujet

    Synonyms: GTP binding mitogen induced T cell protein, GTP binding protein expressed in mitogen stimulated T cells, GTP binding protein GEM, GTP binding protein overexpressed in skeletal muscle, Kinase inducible Ras like protein, KIR, MGC26294, RAS like protein KIR, GEM_HUMAN.

    Background: Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodulin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278297 in human Rad. High intracellular Gem levels, which interact with intact microtubules and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimulate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regulates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome ,8q22.1.

    ID gène
    2669
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