In eukaryotic cells, the Golgi apparatus receives newly synthesized proteins from the endoplasmic reticulum (ER) and, after covalent modification, delivers them to their destination in the cell. For membrane-directed proteins this process is believed to be carried out via vesicular transport. Correct vesicular transport is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). Unconventional SNARE in the ER 1, also known as USE1 or protein p31, is a 259 amino acid t-SNARE that forms a larger complex with ZW10, RINT-1 and Syntaxin 18. Upon Mg2+-AP treatment in the presence of NSF and ?SNAP, ZW10, RINT-1 and USE1 dissociate from Syntaxin 18. USE1 is a single-pass type IV membrane protein that is localized to the endoplasmic reticulum membrane. Three named isoforms exist for USE1 as a result of alternative splicing events.
Synonyms: 2010315L10Rik, 5730403H22Rik, AV002165, D12, Ed2, Embryonic development factor 2, MDS032, P31, Protein D12, Protein p31, putative MAPK activating protein PM26, Putative MAPK-activating protein PM26, Q-snare, RGD1306660, SLT1, SNARE-like tail-anchored protein 1 homolog, Unconventional SNARE in the ER 1 homolog S. cerevisiae, Unconventional SNARE in the ER 1 homolog, Use1, USE1 like protein, Use1 unconventional SNARE in the ER 1 homolog S. cerevisiae, USE1-like protein, USE1_HUMAN, USE1L, Vesicle transport protein USE1.