This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Synonyms: GIRK1 phospho S185, p-GIRK1 phospho S185, inwardly rectying subfamily J member 3, G protein activated inward rectier potassium channel 1, G protein-activated inward rectier potassium channel 1, GIRK-1, Inward rectier K+ channel Kir3.1, Inwardly rectying potassium channel KIR3.1, IRK3, IRK3_HUMAN, Kcnf3, Kcnj3, KGA, KGB1, Kir3.1, Potassium channel, Potassium channel, inwardly rectying subfamily J member 3, Potassium inwardly-rectying channel, subfamily J, member 3.