Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Synonyms: FOXL2 phospho S263, p-FOXL2 phospho S263, blepharophimosis, Blepharophimosis epicanthus inversus and ptosis 1, Blepharophimosis epicanthus inversus and ptosis, BPES 1, BPES, BPES1, epicanthus inversus and ptosis 1, forkhead box L2, Forkhead box protein L2, forkhead transcription factor FOXL2, FOX L2, FOXL 2, FOXL2, FOXL2_HUMAN, PFRK, PINTO, POF 3, POF3.