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TAZ anticorps (Tafazzin) (AA 15-70) Primary Antibody

TAZ Reactivité: Humain, Souris, Rat IF (p), IHC (p), WB Hôte: Lapin Polyclonal
Pubmed (2)
N° du produit ABIN1713913
$339.90
Plus shipping costs $45.00
100 μL
local_shipping Destination: Etats-Unis
Envoi sous 4 à 6 jours ouvrables
  • Antigène
    Épitope
    AA 15-70
    Reactivité
    Humain, Souris, Rat
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Conjugué
    Cet anticorp TAZ est non-conjugé
    Application
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human TAZ
    Isotype
    IgG
  • Indications d'application
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C
    Date de péremption
    12 months
  • Ukita, Yamaguchi, Ohata, Tamura: "Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells." dans: Journal of cellular biochemistry, Vol. 117, Issue 6, pp. 1419-28, 2016 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Mouse (Murine)).

    Sun, Chen, Shi, Qi, Zhao, Zhang: "Prognostic impact of TAZ and ?-catenin expression in adenocarcinoma of the esophagogastric junction." dans: Diagnostic pathology, Vol. 9, pp. 125, 2014 (PubMed). Méthode utilisée: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Échantillon (espèces): Human).

  • Antigène
    Autre désignation
    Taz (TAZ Antibody Extrait)
    Sujet

    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: TAZ, WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1

    ID gène
    25937
    UniProt
    Q9GZV5
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