HDAC3 anticorps (AA 31-130)

N° du produit ABIN1714005

Détail du produit anti-HDAC3 anticorps

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Épitope: AA 31-130

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HDAC3/HD3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur HDAC3

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Autre désignation: HDAC3/HD3 (HDAC3 Produits)

Synonymes: anticorps CG2128, anticorps DHDAC3, anticorps DmHDAC3, anticorps Dmel\\CG2128, anticorps Dromel_CG2128_FBtr0078767_hdac3_mORF, anticorps HDAC, anticorps HDAC3, anticorps Hdac 3, anticorps dHDAC3, anticorps dmHDA402, anticorps hdac3, anticorps HDm, anticorps hd3, anticorps RPD3, anticorps XRpd3, anticorps rpd3-2, anticorps HD3, anticorps RPD3-2, anticorps AW537363, anticorps zgc:55927, anticorps Histone deacetylase 3, anticorps histone deacetylase 3, anticorps histone deacetylase 3 S homeolog, anticorps HDAC3, anticorps hdac3, anticorps CNL05260, anticorps Hdac3, anticorps hdac3.S

Sujet:

Synonyms: HD3, RPD3, RPD3-2, Histone deacetylase 3, SMAP45, HDAC3

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

ID gène: 8841

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development