POLD1 anticorps (AA 101-200)

N° du produit ABIN1714356

Détail du produit anti-POLD1 anticorps

Antigène: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Épitope: AA 101-200

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DNA polymerase delta

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur POLD1

Antigène: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Autre désignation: DNA polymerase delta (POLD1 Produits)

Synonymes: anticorps CDC2, anticorps CRCS10, anticorps POLD, anticorps 5949, anticorps CAA61369, anticorps CG5949, anticorps DNA Pol Delta, anticorps Dm Poldelta, anticorps Dmel\\CG5949, anticorps Poldelta, anticorps dnapol delta, anticorps l(3)72Ac, anticorps cdc2, anticorps pold, anticorps 125kDa, anticorps Pol delta, anticorps fla, anticorps im:7139126, anticorps zgc:152688, anticorps DNA polymerase delta 1, catalytic subunit, anticorps DNA-polymerase-delta, anticorps polymerase (DNA directed), delta 1, catalytic subunit, anticorps DNA polymerase delta catalytic subunit, anticorps DNA polymerase delta, anticorps POLD1, anticorps DNApol-delta, anticorps pold1, anticorps LOC100456571, anticorps Pold1

Sujet:

Synonyms: DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2.

Background: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol , _, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).

ID gène: 5425

Pathways: Telomere Maintenance, Réparation de l'ADN, DNA Replication, Chromatin Binding, Synthesis of DNA