CYP1B1 anticorps (AA 441-543)

N° du produit ABIN1714432

Détail du produit anti-CYP1B1 anticorps

Antigène: CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))

Épitope: AA 441-543

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP1B1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CYP1B1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CYP1B1

Antigène: CYP1B1 (Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1))

Autre désignation: CYP1B1 (CYP1B1 Produits)

Synonymes: anticorps CP1B, anticorps CYPIB1, anticorps GLC3A, anticorps P4501B1, anticorps P4501b1, anticorps CYP1B1, anticorps CYP1B, anticorps zgc:136223, anticorps cytochrome P450 family 1 subfamily B member 1, anticorps cytochrome P450, family 1, subfamily b, polypeptide 1, anticorps cytochrome P450, family 1, subfamily B, polypeptide 1, anticorps cytochrome P450 1B1, anticorps CYP1B1, anticorps Cyp1b1, anticorps cyp1b1, anticorps LOC100719054

Sujet:

Synonyms: CP1B, GLC3A, CYPIB1, P4501B1, Cytochrome P450 1B1, CYP1B1

Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.

ID gène: 1545

UniProt: Q16678

Pathways: Steroid Hormone Biosynthesis