NPC1 anticorps (AA 34-174)

N° du produit ABIN1724876

Détail du produit anti-NPC1 anticorps

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Épitope: AA 34-174

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPC1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: purified

Immunogène: Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli.

Clone: 8D10B6

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-NPC1 (ABIN1724876)

Morales, Amigo, Balboa, Acuña, Castro, Molina, Miquel, Nervi, Rigotti, Zanlungo: "Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice." dans: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 6, pp. 887-97, (2010) (PubMed).

Xu, Zhou, Xia, Xia, Chen, Duan, Luo: "Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons." dans: Neuroscience, Vol. 167, Issue 3, pp. 608-20, (2010) (PubMed).

Détails sur NPC1

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Autre désignation: NPC1 (NPC1 Produits)

Synonymes: anticorps NPC, anticorps 9130221N23Rik, anticorps Gm243, anticorps Cdig2, anticorps im:7149020, anticorps wu:fb53a12, anticorps wu:fc29a12, anticorps A430089E03Rik, anticorps C85354, anticorps D18Ertd139e, anticorps D18Ertd723e, anticorps lcsd, anticorps nmf164, anticorps spm, anticorps NPC intracellular cholesterol transporter 1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps Niemann-Pick disease, type C1, anticorps Niemann-Pick C1 protein, anticorps NPC1, anticorps Npc1l1, anticorps Npc1, anticorps npc1, anticorps LOC579887

Sujet:

Description: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. ,

Aliases: NPC

Poids moléculaire: 142.2 kDa

ID gène: 4864

HGNC: 4864