Raptor anticorps (AA 874-1009)

N° du produit ABIN1724920

Détail du produit anti-Raptor anticorps

Antigène: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Épitope: AA 874-1009

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Raptor est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: purified

Immunogène: Purified recombinant fragment of human RPTOR (AA: 874-1009) expressed in E. coli.

Clone: 6G9C4

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-Raptor (ABIN1724920)

Vazquez-Martin, Cufí, Oliveras-Ferraros, Menendez: "Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)." dans: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 18, pp. 3140-52, (2011) (PubMed).

Sun, Southard, Witonsky, Kittler, Di Rienzo: "Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations." dans: PLoS genetics, Vol. 6, Issue 10, pp. e1001178, (2010) (PubMed).

Détails sur Raptor

Antigène: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Autre désignation: RPTOR (RPTOR Produits)

Synonymes: anticorps KOG1, anticorps Mip1, anticorps 4932417H02Rik, anticorps Rap, anticorps Raptor, anticorps mKIAA1303, anticorps RGD1311784, anticorps raptor, anticorps regulatory associated protein of MTOR complex 1, anticorps regulatory associated protein of MTOR, complex 1, anticorps regulatory associated protein of MTOR, complex 1 L homeolog, anticorps RPTOR, anticorps Rptor, anticorps rptor.L, anticorps rptor

Sujet:

Description: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. ,

Aliases: KOG1, Mip1

Poids moléculaire: 149 kDa

ID gène: 57521

HGNC: 57521

Pathways: Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, L'effet Warburg