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FcRn anticorps

FcRn Reactivité: Humain, Souris ELISA, IF, FACS, cELISA Hôte: Souris Monoclonal DVN24 unconjugated
N° du produit ABIN1774763
  • Antigène Voir toutes FcRn Anticorps
    FcRn (IgG receptor FcRn (FcRn))
    Reactivité
    • 39
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 38
    • 6
    • 1
    Souris
    Clonalité
    • 39
    • 6
    Monoclonal
    Conjugué
    • 20
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FcRn est non-conjugé
    Application
    • 29
    • 25
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)
    Attributs du produit
    based on recognition of the complete native protein expressed on transfected mammalian cells
    Purification
    Purified, Protein A
    Immunogène
    Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.
    Clone
    DVN24
    Isotype
    IgG2a
    Top Product
    Discover our top product FcRn Anticorps primaire
  • Indications d'application
    Flow cytometry: 1.2 μg/10^6 cells ELISA: 1:200 - 1:400CELISA: 1:200 - 1:400For each application a titration should be performed to determine the optimal concentration.
    Restrictions
    For Research Use only
  • Buffer
    phosphate buffered saline, pH 7.2
    Conseil sur la manipulation
    avoid repeated freezing and thawing
    Stock
    4 °C
  • Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

    Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

  • Antigène
    FcRn (IgG receptor FcRn (FcRn))
    Abstract
    FcRn Produits
    Synonymes
    anticorps FCRN, anticorps alpha-chain, anticorps FcRn, anticorps Fc fragment of IgG receptor and transporter, anticorps Fc receptor, IgG, alpha chain transporter, anticorps FCGRT, anticorps Fcgrt
    Sujet
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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