KCNK18 anticorps (Potassium Channel Subfamily K Member 18) (AA 10-100)

N° du produit ABIN1842068

Détail du produit anti-KCNK18 anticorps

Antigène:

KCNK18

Épitope: AA 10-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK18 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificité: Specific for KCNK18.

Purification: Whole serum

Immunogène: A synthetic peptide from aa region of 10-100 of human KCNK18 (TRESK, KCNKI) conjugated to an immunogenic carrier protein was used as the antigen.

Information d'application

Indications d'application: A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur KCNK18

Antigène:

KCNK18

Autre désignation: KCNK18 (KCNK18 Antibody Extrait)

Sujet: Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents. Defects in KCNK18 are a cause of migraine with or without aura type 13 (MGR13). Mutations in KCNK18 are a rare cause of migraine. Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, trigeminal ganglion neurons, spinal cord and testis. Subcellular location: Membrane, Multi-pass membrane protein.
Synonyms: Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI