NPC1 anticorps (AA 34-174)

N° du produit ABIN1845969

Détail du produit anti-NPC1 anticorps

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Épitope: AA 34-174

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPC1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: Purified

Immunogène: Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli.

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Détails sur NPC1

Antigène: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Autre désignation: NPC1 (NPC1 Produits)

Synonymes: anticorps NPC, anticorps 9130221N23Rik, anticorps Gm243, anticorps Cdig2, anticorps im:7149020, anticorps wu:fb53a12, anticorps wu:fc29a12, anticorps A430089E03Rik, anticorps C85354, anticorps D18Ertd139e, anticorps D18Ertd723e, anticorps lcsd, anticorps nmf164, anticorps spm, anticorps NPC intracellular cholesterol transporter 1, anticorps NPC1 like intracellular cholesterol transporter 1, anticorps Niemann-Pick disease, type C1, anticorps Niemann-Pick C1 protein, anticorps NPC1, anticorps Npc1l1, anticorps Npc1, anticorps npc1, anticorps LOC579887

Sujet: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus.This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Poids moléculaire: 142.2 kDa