CD46 anticorps (AA 330-361)

N° du produit ABIN1881186

Détail du produit anti-CD46 anticorps

Antigène: CD46

Épitope: AA 330-361

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CD46 (ABIN1881186)

Riley, Kemper, Leung, Atkinson: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." dans: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).

Cervoni, Fenichel, Akhoundi, Hsi, Rossi: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." dans: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, (1993) (PubMed).

Post, Liszewski, Adams, Tedja, Miller, Atkinson: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." dans: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, (1991) (PubMed).

Purcell, Russell, Deacon, Brown, Hooker, McKenzie: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." dans: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, (1991) (PubMed).

Lublin, Liszewski, Post, Arce, Le Beau, Rebentisch, Lemons, Seya, Atkinson: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." dans: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, (1988) (PubMed).

Détails sur CD46

Antigène: CD46

Autre désignation: CD46 (CD46 Produits)

Synonymes: anticorps AHUS2, anticorps MCP, anticorps MIC10, anticorps TLX, anticorps TRA2.10, anticorps Mcp, anticorps CD46, anticorps CD46 molecule, anticorps CD46 antigen, complement regulatory protein, anticorps CD46 molecule, complement regulatory protein, anticorps membrane cofactor protein-like, anticorps CD46, anticorps Cd46, anticorps LOC100341359, anticorps LOC103789310

Sujet: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Poids moléculaire: 43747

NCBI Accession: NP_002380, NP_722548, NP_758860, NP_758861, NP_758862, NP_758863, NP_758869, NP_758871

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization