GRB10 anticorps (N-Term)

N° du produit ABIN1881389

Détail du produit anti-GRB10 anticorps

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB10 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GRB10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GRB10.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GRB10 (ABIN1881389)

Nantel, Mohammad-Ali, Sherk, Posner, Thomas: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." dans: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).

Frantz, Giorgetti-Peraldi, Ottinger, Shoelson: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." dans: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).

Dong, Du, Porter, Kolakowski, Lee, Mandarino, Fan, Yee, Liu, Mandarino: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." dans: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).

ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." dans: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).

Liu, Roth: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).

Détails sur GRB10

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Autre désignation: GRB10 (GRB10 Produits)

Synonymes: anticorps grb10, anticorps zgc:91987, anticorps GRB10, anticorps grb-10, anticorps grb-ir, anticorps irbp, anticorps meg1, anticorps rss, anticorps LOC100224775, anticorps 5730571D09Rik, anticorps AI325020, anticorps Meg1, anticorps mKIAA0207, anticorps RGD1566234, anticorps GRB-IR, anticorps Grb-10, anticorps IRBP, anticorps MEG1, anticorps RSS, anticorps growth factor receptor bound protein 10, anticorps growth factor receptor-bound protein 10a, anticorps growth factor receptor bound protein 10 L homeolog, anticorps growth factor receptor-bound protein 10, anticorps GRB10, anticorps grb10a, anticorps grb10, anticorps grb10.L, anticorps LOC100434903, anticorps Grb10

Sujet: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Poids moléculaire: 67231

NCBI Accession: NP_001001549, NP_001001550, NP_001001555, NP_005302

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2