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ErbB2/Her2 anticorps (pTyr1112)

ErbB2/Her2 Reactivité: Humain WB, DB Hôte: Lapin Polyclonal RB41955 unconjugated
N° du produit ABIN1881408
  • Antigène Voir toutes ErbB2/Her2 Anticorps
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Épitope
    • 32
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    pTyr1112
    Reactivité
    • 518
    • 187
    • 164
    • 34
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
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    • 1
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    • 1
    Humain
    Hôte
    • 409
    • 156
    • 11
    • 5
    • 3
    • 3
    Lapin
    Clonalité
    • 412
    • 172
    • 2
    Polyclonal
    Conjugué
    • 269
    • 46
    • 38
    • 29
    • 25
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    • 3
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    • 3
    • 3
    • 1
    • 1
    Cet anticorp ErbB2/Her2 est non-conjugé
    Application
    • 300
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    • 139
    • 104
    • 95
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    • 80
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    • 1
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    • 1
    Western Blotting (WB), Dot Blot (DB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This HER2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1112 of human HER2.
    Clone
    RB41955
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ErbB2/Her2 Anticorps primaire
  • Indications d'application
    WB: 1:2000. DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Brandt, Mikesch, Simon, Rötger, Kemming, Schier, Sauter, Bürger: "Selective expression of a splice variant of decay-accelerating factor in c-erbB-2-positive mammary carcinoma cells showing increased transendothelial invasiveness." dans: Biochemical and biophysical research communications, Vol. 329, Issue 1, pp. 318-23, (2005) (PubMed).

    Ghatak, Misra, Toole: "Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells." dans: The Journal of biological chemistry, Vol. 280, Issue 10, pp. 8875-83, (2005) (PubMed).

    Provinciali, Re, Donnini, Orlando, Bartozzi, Di Stasio, Smorlesi: "Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice." dans: International journal of cancer. Journal international du cancer, Vol. 115, Issue 1, pp. 36-45, (2005) (PubMed).

    Yee, Young, Rosol, Vanbuskirk, Clinton: "Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone." dans: The Journal of nutrition, Vol. 135, Issue 5, pp. 983-8, (2005) (PubMed).

    Beckers, Herrmann, Rieger, Drobyshev, Horsch, Hrabé de Angelis, Seliger: "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis." dans: International journal of cancer. Journal international du cancer, Vol. 114, Issue 4, pp. 590-7, (2005) (PubMed).

  • Antigène
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Autre désignation
    HER2 (ErbB2/Her2 Produits)
    Synonymes
    anticorps CD340, anticorps HER-2, anticorps HER-2/neu, anticorps HER2, anticorps MLN 19, anticorps NEU, anticorps NGL, anticorps TKR1, anticorps Erbb-2, anticorps Neu, anticorps c-erbB2, anticorps c-neu, anticorps mKIAA3023, anticorps wu:fv70f10, anticorps zgc:63601, anticorps erb2, anticorps erb-b2 receptor tyrosine kinase 2, anticorps ERBB2, anticorps Erbb2, anticorps erbb2
    Sujet
    ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
    Poids moléculaire
    137910
    NCBI Accession
    NP_001005862, NP_004439
    UniProt
    P04626
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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