PROX1 anticorps (AA 175-206)

N° du produit ABIN1881686

Détail du produit anti-PROX1 anticorps

Antigène: PROX1 (Prospero Homeobox 1 (PROX1))

Épitope: AA 175-206

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PROX1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-206 amino acids from human PROX1.

Clone: RB15516

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PROX1 (ABIN1881686)

Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies." dans: Genes, chromosomes & cancer, Vol. 38, Issue 1, pp. 13-21, (2003) (PubMed).

Hong, Harvey, Noh, Schacht, Hirakawa, Detmar, Oliver: "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate." dans: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 225, Issue 3, pp. 351-7, (2002) (PubMed).

Petrova, Mäkinen, Mäkelä, Saarela, Virtanen, Ferrell, Finegold, Kerjaschki, Ylä-Herttuala, Alitalo: "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor." dans: The EMBO journal, Vol. 21, Issue 17, pp. 4593-9, (2002) (PubMed).

Mouta Carreira, Nasser, di Tomaso, Padera, Boucher, Tomarev, Jain: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." dans: Cancer research, Vol. 61, Issue 22, pp. 8079-84, (2001) (PubMed).

Détails sur PROX1

Antigène: PROX1 (Prospero Homeobox 1 (PROX1))

Autre désignation: PROX1 (PROX1 Produits)

Synonymes: anticorps xprox1, anticorps prospero, anticorps PROX1, anticorps LOC100232600, anticorps A230003G05Rik, anticorps prox1, anticorps zgc:111888, anticorps prospero homeobox 1, anticorps prospero homeobox 1 L homeolog, anticorps prospero homeobox 1a, anticorps PROX1, anticorps prox1.L, anticorps prox1, anticorps Prox1, anticorps prox1a

Sujet: The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.

Poids moléculaire: 83203

NCBI Accession: NP_001257545, NP_002754

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation