This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This RFFL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human RFFL.
RFFL
Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." dans: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).
Newton-Cheh, Eijgelsheim, Rice, de Bakker, Yin, Estrada, Bis, Marciante, Rivadeneira, Noseworthy, Sotoodehnia, Smith, Rotter, Kors, Witteman, Hofman, Heckbert: "Common variants at ten loci influence QT interval duration in the QTGEN Study." dans: Nature genetics, Vol. 41, Issue 4, pp. 399-406, (2009) (PubMed).
Hosgood, Zhang, Shen, Berndt, Vermeulen, Li, Yin, Yeager, Yuenger, Rothman, Chanock, Smith, Lan: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." dans: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, (2009) (PubMed).
Liao, Xiao, Tchikov, Fujita, Yang, Wincovitch, Garfield, Conze, El-Deiry, Schütze, Srinivasula: "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation." dans: Current biology : CB, Vol. 18, Issue 9, pp. 641-9, (2008) (PubMed).
Yang, Dicker, Chen, El-Deiry: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." dans: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, (2008) (PubMed).
Antigène
RFFL
(Ring Finger and FYVE-Like Domain Containing 1 (RFFL))
anticorps MGC84042, anticorps RFFL, anticorps Rffl, anticorps 1700051E09Rik, anticorps 4930516L10Rik, anticorps BG080975, anticorps Carp2, anticorps CARP-2, anticorps CARP2, anticorps FRING, anticorps RIFIFYLIN, anticorps RNF189, anticorps RNF34L, anticorps ring finger and FYVE like domain containing E3 ubiquitin protein ligase, anticorps ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog, anticorps ring finger and FYVE-like domain containing 1, anticorps ring finger and FYVE like domain containing protein, anticorps ring finger and FYVE-like domain containing E3 ubiquitin protein ligase, anticorps RFFL, anticorps rffl.L, anticorps Rffl
Sujet
RFFL has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.