RFWD2 anticorps (C-Term)

N° du produit ABIN1881747

Détail du produit anti-RFWD2 anticorps

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Épitope: AA 672-701, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFWD2 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RFWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of human RFWD2.

Clone: RB41831

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-RFWD2 (ABIN1881747)

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." dans: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Li, Ohshiro, Reddy, Pakala, Lee, Zhang, Rayala, Kumar: "E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 41, pp. 17493-8, (2009) (PubMed).

Kato, Ding, Pisck, Jhala, Du: "COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression." dans: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35464-73, (2008) (PubMed).

Détails sur RFWD2

Antigène: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Autre désignation: RFWD2 (RFWD2 Produits)

Synonymes: anticorps COP1, anticorps RNF200, anticorps AI316802, anticorps C80879, anticorps Cop1, anticorps RGD1304773, anticorps RFWD2, anticorps cop1, anticorps rnf200, anticorps zgc:163067, anticorps ring finger and WD repeat domain 2, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, anticorps ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog, anticorps RFWD2, anticorps Rfwd2, anticorps rfwd2, anticorps rfwd2.L

Sujet: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

Poids moléculaire: 80474

NCBI Accession: NP_001001740, NP_071902

UniProt: Q8NHY2

Pathways: Photoperiodism