This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This SPTLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-401 amino acids from the Central region of human SPTLC2.
SPTLC2
Reactivité: Humain, Souris, Rat
WB, IF, IHC (p), EIA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Rotthier, Auer-Grumbach, Janssens, Baets, Penno, Almeida-Souza, Van Hoof, Jacobs, De Vriendt, Schlotter-Weigel, Löscher, Vondráček, Seeman: "Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I." dans: American journal of human genetics, Vol. 87, Issue 4, pp. 513-22, (2010) (PubMed).
Han, Gupta, Gable, Niranjanakumari, Moitra, Eichler, Brown, Harmon, Dunn: "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 20, pp. 8186-91, (2009) (PubMed).
Chen, Han, Dietrich, Dunn, Cahoon: "The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase." dans: The Plant cell, Vol. 18, Issue 12, pp. 3576-93, (2007) (PubMed).
Hornemann, Wei, von Eckardstein: "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?" dans: The Biochemical journal, Vol. 405, Issue 1, pp. 157-64, (2007) (PubMed).
Antigène
SPTLC2
(serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))
anticorps HSN1C, anticorps LCB2, anticorps LCB2A, anticorps NSAN1C, anticorps SPT2, anticorps hLCB2a, anticorps sptlc2, anticorps zgc:110661, anticorps AI173915, anticorps mKIAA0526, anticorps Pomt2, anticorps LCB2a, anticorps SPTLC2, anticorps serine palmitoyltransferase long chain base subunit 2, anticorps serine palmitoyltransferase 2, anticorps serine palmitoyltransferase, long chain base subunit 2 S homeolog, anticorps serine palmitoyltransferase, long chain base subunit 2a, anticorps serine palmitoyltransferase, long chain base subunit 2, anticorps SPTLC2, anticorps LOC100446763, anticorps sptlc2, anticorps sptlc2.S, anticorps sptlc2a, anticorps Sptlc2
Sujet
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.