TGFBR1 anticorps (AA 145-172)

N° du produit ABIN1881880

Détail du produit anti-TGFBR1 anticorps

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Épitope: AA 145-172

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFBR1 est non-conjugé

Application: Western Blotting (WB)

Homologie: B, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TGFBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the Central region of human TGFBR1.

Clone: RB43638

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur TGFBR1

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Autre désignation: TGFBR1 (TGFBR1 Produits)

Synonymes: anticorps AAT5, anticorps ACVRLK4, anticorps ALK-5, anticorps ALK5, anticorps LDS1A, anticorps LDS2A, anticorps MSSE, anticorps SKR4, anticorps TGFR-1, anticorps aat5, anticorps acvrlk4, anticorps alk-5, anticorps alk5, anticorps lds1a, anticorps lds2a, anticorps skr4, anticorps tgfr-1, anticorps TGFBR1, anticorps x-trr1, anticorps AU017191, anticorps Alk-5, anticorps TbetaR-I, anticorps TbetaRI, anticorps Alk5, anticorps Skr4, anticorps Tgfr-1, anticorps tbetaR-I, anticorps tgfbr1, anticorps zgc:123263, anticorps transforming growth factor beta receptor 1, anticorps transforming growth factor beta receptor I, anticorps transforming growth factor beta receptor I S homeolog, anticorps transforming growth factor, beta receptor I, anticorps transforming growth factor, beta receptor 1, anticorps transforming growth factor, beta receptor 1 a, anticorps TGFBR1, anticorps tgfbr1, anticorps tgfbr1.S, anticorps Tgfbr1, anticorps tgfbr1a

Sujet: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

Poids moléculaire: 55960

NCBI Accession: NP_001124388, NP_004603

UniProt: P36897

Pathways: Growth Factor Binding