UBR1 anticorps (N-Term)

N° du produit ABIN1881972

Détail du produit anti-UBR1 anticorps

Antigène: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Épitope: AA 245-274, N-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBR1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.

Clone: RB41861

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-UBR1 (ABIN1881972)

Alkhouri, Kaplan, Kay, Shealy, Crowe, Bauhuber, Zenker: "Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing." dans: World journal of gastroenterology : WJG, Vol. 14, Issue 44, pp. 6863-6, (2008) (PubMed).

Wei, Lin, Yang, Wang, Chang, Chen, Chen et al.: "Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of..." dans: Molecular pharmacology, Vol. 72, Issue 3, pp. 725-33, (2007) (PubMed).

Détails sur UBR1

Antigène: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Autre désignation: UBR1 (UBR1 Produits)

Synonymes: anticorps Dmel\\CG9086, anticorps Ubr1, anticorps UBR1, anticorps JBS, anticorps AI504731, anticorps RGD1562326, anticorps Ubr1 ubiquitin ligase, anticorps ubiquitin protein ligase E3 component n-recognin 1, anticorps E3 ubiquitin-protein ligase ubr-1, anticorps Ubr1, anticorps ubr1, anticorps UBR1, anticorps ubr-1

Sujet: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Poids moléculaire: 200211

NCBI Accession: NP_777576

UniProt: Q8IWV7