FGFR1 anticorps (N-Term)

N° du produit ABIN1882081

Détail du produit anti-FGFR1 anticorps

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Épitope: AA 19-48, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~48 amino acids from the N-terminal region of human FGFR1.

Clone: RB04521

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:50~100. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-FGFR1 (ABIN1882081)

Hirata, Katayama, Tsuji, Imura, Natsume, Sugahara, Kunieda, Nakamura, Otsuki: "Homeobox family Hoxc localization during murine palate formation." dans: Congenital anomalies, Vol. 56, Issue 4, pp. 172-9, (2016) (PubMed).

Mohanan, Temburni, Kappes, Galileo: "L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor." dans: Clinical & experimental metastasis, Vol. 30, Issue 4, pp. 507-20, (2013) (PubMed).

Kamura, Matsumoto, Fukushi, Fujiwara, Iida, Okada, Iwamoto: "Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway." dans: British journal of cancer, Vol. 103, Issue 3, pp. 370-81, (2010) (PubMed).

Page, Ambady, Holmes, Vilner, Kole, Kashpur, Huntress, Vojtic, Whitton, Dominko: "Induction of stem cell gene expression in adult human fibroblasts without transgenes." dans: Cloning and stem cells, Vol. 11, Issue 3, pp. 417-26, (2009) (PubMed).

Mondrinos, Koutzaki, Lelkes, Finck: "A tissue-engineered model of fetal distal lung tissue." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 293, Issue 3, pp. L639-50, (2007) (PubMed).

Sahni, Francis: "Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3." dans: Blood, Vol. 104, Issue 12, pp. 3635-41, (2004) (PubMed).

Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: "Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite." dans: Archives of biochemistry and biophysics, Vol. 410, Issue 2, pp. 187-200, (2003) (PubMed).

Fu, Abu-Khalil, Morrison, Geschwind, Kornblum: "Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain." dans: The Journal of comparative neurology, Vol. 462, Issue 2, pp. 265-73, (2003) (PubMed).

Lundin, Rönnstrand, Cross, Hellberg, Lindahl, Claesson-Welsh: "Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin." dans: Experimental cell research, Vol. 287, Issue 1, pp. 190-8, (2003) (PubMed).

Kiselyov, Skladchikova, Hinsby, Jensen, Kulahin, Soroka, Pedersen, Tsetlin, Poulsen, Berezin, Bock: "Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP." dans: Structure (London, England : 1993), Vol. 11, Issue 6, pp. 691-701, (2003) (PubMed).

Baumann, Kunapuli, Tracy, Cowell: "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors." dans: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16198-208, (2003) (PubMed).

Hauge: "[Expeditions to high altitudes--what can we learn from them?]." dans: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Vol. 111, Issue 8, pp. 926-8, (1991) (PubMed).

Détails sur FGFR1

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1 (FGFR1 Produits)

Synonymes: anticorps FGFR, anticorps fgfr, anticorps X1FGFR, anticorps XFGFR-1, anticorps XFGFRA2, anticorps bfgfr, anticorps cek, anticorps fgfr1, anticorps flg, anticorps flt-2, anticorps flt2, anticorps kal2, anticorps ogd, anticorps xfgfr1, anticorps CG7223, anticorps CT22273, anticorps CT39172, anticorps DFGF-R1, anticorps DFGF-R2, anticorps DFR-1, anticorps DFR1, anticorps DFR1/DFGF-R2, anticorps DPR3, anticorps DTRK(FR1), anticorps Dfr-1, anticorps Dfr1, anticorps DmHD-38, anticorps Dmel\\CG7223, anticorps Dtk1, anticorps EMS2, anticorps FGF-R2, anticorps FGFR2, anticorps FR1, anticorps Fr1, anticorps HD-38, anticorps HTL/FGFR1, anticorps Htl, anticorps Tk1, anticorps dtk1, anticorps i100, anticorps i150, anticorps i79, anticorps j372, anticorps cd331, anticorps fgfbr, anticorps fgfr-1, anticorps hbgfr, anticorps n-sam, anticorps ach, anticorps cd333, anticorps cek2, anticorps fgfr-3, anticorps hsfgfr3ex, anticorps jtk4, anticorps BFGFR, anticorps CD331, anticorps CEK, anticorps FGFBR, anticorps FGFR-1, anticorps FLG, anticorps FLT-2, anticorps FLT2, anticorps HBGFR, anticorps HH2, anticorps KAL2, anticorps N-SAM, anticorps OGD, anticorps bFGF-R-1, anticorps AW208770, anticorps Eask, anticorps Fgfr-1, anticorps Flt-2, anticorps Hspy, anticorps FLG-1, anticorps FGFRI, anticorps x1fgfr, anticorps cb231, anticorps sb:cb231, anticorps fibroblast growth factor receptor, anticorps fibroblast growth factor receptor 1 S homeolog, anticorps basic fibroblast growth factor receptor 1, anticorps heartless, anticorps fibroblast growth factor receptor 1, anticorps fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog, anticorps Fibroblast growth factor receptor 1, anticorps fibroblast growth factor receptor 1 L homeolog, anticorps fibroblast growth factor receptor 1a, anticorps FGFR, anticorps fgfr, anticorps fgfr1.S, anticorps CpipJ_CPIJ005849, anticorps htl, anticorps fgfr1, anticorps fgfr3.L, anticorps FGFR1, anticorps Fgfr1, anticorps fgfr1.L, anticorps fgfr1a

Sujet: FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.

Poids moléculaire: 91868

NCBI Accession: NP_001167534, NP_001167535, NP_001167536, NP_001167537, NP_001167538, NP_056934, NP_075593, NP_075594, NP_075598

UniProt: P11362

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins